Sciencescience

Thu Feb 14, 2019, 04:48 PM

Biological sex shapes tumour evolution across cancer types



A coloured SEM of the surface details of a hepatocellular carcinoma (HCC) cell.

Liver cancer is associated with different genetic mutations based on a person's biological sex. Credit: Steve Gschmeissner/Science Photo Library

A person’s sex can affect the kinds of cancer-causing mutations they develop, according to a genomic analysis spanning nearly 2,000 tumours and 28 types of cancer.

The results show striking differences in the cancer-causing mutations found in people who are biologically male versus those who are biologically female — not only in the number of mutations lurking in their tumours, but also in the kinds of mutations found there.

Liver tumours from women were more likely to carry mutations caused by a faulty system of DNA mending called mismatch repair, for instance. And men with any type of cancer were more likely to exhibit DNA changes thought to be linked to a process that the body uses to repair DNA with two broken strands.

These biases could point researchers to key biological differences in how tumours develop and evolve across sexes. (The study did not look at the gender of those who donated tissue samples, which could differ from their biological sex.) The work was published last month as a preprint on the bioRxiv server.

https://www.nature.com/articles/d41586-019-00562-7

Not looking at gender would seem to be a big problem with this study.

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Reply Biological sex shapes tumour evolution across cancer types (Original post)
Troll2 Feb 2019 OP
Let it go Feb 2019 #1

Response to Troll2 (Original post)

Thu Feb 14, 2019, 05:39 PM

1. Can a doctor be sued for treating a transgender for their biological sex?

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