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Thu Jul 28, 2016, 09:35 AM

Breakthrough as scientists create first drug to halt Alzheimer's disease

A pill taken twice a day has stalled deterioration of the brain in Alzheimer’s patients for the first time.

Scientists announced that the mental decline of participants in a final-stage trial had been halted for 18 months, raising hopes that an effective treatment for the drug, called LMTX, is close at hand.

Patients saw no weakening of their memory and reasoning skills over the year and a half they were taking the pills, and their ability to undertake everyday tasks remained the same.

http://www.telegraph.co.uk/news/2016/07/27/first-drug-to-halt-alzheimers-tested-by-scientists/

Unprecedented Alzheimer’s drug slows disease by 80 per cent

https://www.newscientist.com/article/2099108-unprecedented-alzheimers-drug-slows-disease-by-80-per-cent/

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Response to Troll2 (Original post)

Thu Jul 28, 2016, 09:48 AM

1. Medical marijuana has potential as Alzheimer's treatment, study says


Could medical marijuana treat Alzheimer's patients? One recent study found THC, the psychoactive ingredient in cannabis, stimulates the removal of toxic plaque in the brain, a common feature of the disease. Furthermore, the researchers discovered it blocks inflammation, which damages neurons in the brain.

http://www.cnn.com/2016/07/25/health/alzheimers-medical-marijuana/

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Response to Troll2 (Original post)

Thu Jul 28, 2016, 01:00 PM

2. Gee, maybe if Raygun had not trashed medical research in favor of the military and tax-cut

 

bribes to his rich pals, this drug might have been discovered soon enough to save the USA from years of Pres. Brain-Dead ruling by astrologer, bible, and the ramblings of his own, diseased mind.

Think of the suffering that would have been avoided.

If only.

It would have even been worth saving that old bastard's life if others' suffering could have also been alleviated.

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Response to JeffJenk (Reply #2)

Thu Jul 28, 2016, 02:21 PM

3. Wow, you really are taking being an ass to a whole new level.

... from years of Pres. Brain-Dead

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Response to MeatSandwich (Reply #3)

Thu Jul 28, 2016, 02:39 PM

4. Hey, I saw and heard the SOB wander down the California highway in 1984 and knew then that in

 

addition to being an asshole, he was a mentally-deficient asshole who should not be allowed to eat by himself, forget about ruling America.

And just as millions of us knew that Shrub & the Dick were lying about WMDs to gin up phony support for their war-for-profit against the Middle East, we all knew at that early point that the B-actor was unqualified to be POTUS by even the loosest criteria for the job.

The fact that he was mentally ill should garner some sympathy, but he deliberately caused so much harm to the most vulnerable among us and accelerated the rush to create maximum economic disparity so severely that we are still fighting to undo the damage that I cannot work up even the minimum sympathy for the cretin.

My grandfather suffered with Alzheimer's so I know the terrible impact it has on people.
Too bad Raygun and the right never developed a similar empathy for AIDS victims or the victims of conservatism's toxic and perverted policies.

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Response to JeffJenk (Reply #4)

Thu Jul 28, 2016, 03:06 PM

5. As did my father. If you want to be an ass, pick another disease.

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Response to MeatSandwich (Reply #5)

Thu Jul 28, 2016, 03:28 PM

6. Having the disease deserves sympathy. What they do "with" it - not necessarily. An AIDS victim

 

who deliberately infects others as revenge or for some other ideological reason - would you be sympathetic to them?

Wait - AIDS victim. Automatically not sympathetic to conservatives. They "deserve" it, right?

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Response to JeffJenk (Reply #6)

Fri Jul 29, 2016, 09:41 AM

7. Still being an ass. But we already knew that, based on your previous posts.

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Response to Troll2 (Original post)

Sat Aug 13, 2016, 08:40 PM

8. It's a scary thing

to see someone's mind slowly deteriorate like that.

My late MIL wasn't diagnosed with it, but the doctor did say she had dementia, which I suppose is nearly the same.

worst thing was that when she was lucid, she knew that her mind was going.

I'm terrified of ending up like that.

So undignified.

I hope they come up with a treatment.

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Response to Troll2 (Original post)

Tue Aug 23, 2016, 04:14 PM

9. I've been giving my mom an early form of this drug for awhile

The new drug is based on a substance called "methylene blue" which has been available online for years. It was first introduced as a drug called "Rember". It seemed to work with some patients. With it, my mom has shown only a slow decline. They tweaked methylene blue and improved on it. Now this new form supposedly is more effective; more bioavailable and better able to penetrate the blood-brain barrier.

http://taurx.com/lmtx-for-alzheimers.html

wikipedia:

https://en.wikipedia.org/wiki/Methylene_blue

Clinical trials

Methylene blue (methylthioninium chloride), under the brand name Rember, has been investigated for treatment of Alzheimer's dementia. Methylene blue is proposed to affect neurodegeneration in Alzheimer's disease via inhibition of tau protein aggregation. Methylene blue also affects dissociation of amyloids TauRx Therapeutics have reformulated the drug, under the brand name LMTX. This formulation is undergoing phase 3 clinical trials for safety and efficacy as "TRx0237".

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Response to RolandLePreux (Reply #9)

Tue Aug 23, 2016, 08:02 PM

10. TRx0237 is somewhat different from methylthioninium chloride -- no chlorine atom.

Methylene blue is named 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride per http://www.alzforum.org/therapeutics/rember-tm

TRx0237 is named 10H-Phenothiazine-3,7 diamine, N3,N3,N7,N7-tetramethyl

The chemical formula of Methylene blue included a Chlorine while TRx0137 does not and has one more Hydrogen atom.

It may be the methylthioninium without the chloride? But I can't see the structure for TRx0237. It's definitely a different compound, but it is hard to see how different.

TRx0237 Phase III trial reported some success when administered alone, but no when supplementing other Alzheimer drugs. taurx.com/taurx-reports-first-phase-3-results-for-lmtx®.pdf

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